Talimogene Laherparepvec: A groundbreaking viral therapy for late stage melanoma: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[Image: | [[Image: hsvimg01.jpg|thumb|300px|right|<b> Figure 1:</b> Scatter plot representing the effect of <i> Bifidobacterium longum </i> subsp. <i> infantis </i> on intestinal epithelial cell viability. The study was done by O'Hara et al in 2006 [http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2006.02358.x/full].]] | ||
<br>By Alex Fazioli<br> | <br>By Alex Fazioli<br> |
Revision as of 20:32, 2 April 2018
Introduction
By Alex Fazioli
Talimogene Laherparepvec (T-VEC) is an engineered Herpes simplex virus type 1 designed to specifically target, reproduce, and lyse human tumor cells [1]. T-VEC also produces granulocyte macrophage colony-stimulating factor (GM-CSF) to improve the antitumor immune response within the human body upon the lysis of tumor cells [1]. T-VEC avoids infecting non-cancerous cells by having all copies of two key neurovirulence factor genes deleted RL1 and US12 [2]. The deletion of the US12 gene puts its promoter in close proximity to the US11 increasing its expression which has been shown to increase the ability of T-VEC to replicate within tumour cells [3].
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Subscript: H2O
Superscript: Fe3+
Introduce the topic of your paper. What is your research question? What experiments have addressed your question? Applications for medicine and/or environment?
Sample citations: [1]
[2]
A citation code consists of a hyperlinked reference within "ref" begin and end codes.
Classification
Baltimore classification: dsDNA
Family: Herpesviridae
Virion: Enveloped
Capsid symmetry: Icosahedral
Replication site: Nucleus and cytoplasm
Section 2
Include some current research, with at least one figure showing data.
Section 3
Include some current research, with at least one figure showing data.
Section 4
Conclusion
References
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2018, Kenyon College.