Retroviral gene therapy: Difference between revisions

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==Section==
[[Image:PHIL_22882_lores.jpg|thumb|300px|right|This illustration depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. The photo credit for this image belongs to Alissa Eckert, who is a medical illustrator at the [http://www.cdc.gov/ CDC].]]
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Sample citations: <ref name=aa>[https://www.sciencedirect.com/science/article/pii/S016777999901416X?via%3Dihub=Mountain, Andrew. "Gene therapy: the first decade." Trends in biotechnology 18, no. 3 (2000): 119-128.]</ref>
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847443/ Bartlett et al.: Oncolytcaor viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.]</ref>
<br><br>A citation code consists of a hyperlinked reference within "ref" begin and end codes.
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==Introduction to Retrovirus Gene Therapy==
<br> Retroviral therapy is the use of retroviral vectors to provide remedy to disease via the genetic modification of a patient’s own cells. Retroviral vectors are themselves derived from natural retroviruses such as HIV. The name retrovirus refers to the unique ability of these viruses to convert viral RNA into DNA. A critical part of the viral life cycle is the integration of this viral DNA into the host cell’s genome, conferring a permanent genetic change to the cell. Therefore, retroviruses may be used as a vector for gene therapy, a method of treatment dealing specifically with the alteration of genes to achieve a therapeutic effect. Gene therapy techniques are divided into three main categories; viral(including retroviral gene therapy), nonviral, and physical. The use of retroviruses bears a significant advantage over these other forms of gene therapy. Nonviral and physical techniques are less efficient in transfection and, in the case of nonviral vectors, have a more limited expression. Viral techniques, however, are more efficient in transfection and better integrate viral genes into the target genome. <ref name=aa/> <br>
==Section 2==
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</ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847443/ Bartlett et al.: Oncolytcaor viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.]</ref>
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==Section 3==
Include some current research, with at least one figure showing data.
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==Section 4==
==Conclusion==
==References==
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<br><br>Authored for BIOL 238 Microbiology, taught by [mailto:slonczewski@kenyon.edu Joan Slonczewski], 2022, [http://www.kenyon.edu/index.xml Kenyon College]

Revision as of 02:01, 19 April 2022