Globicatella sanguinis: Difference between revisions
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==Ecology and Pathogenesis== | ==Ecology and Pathogenesis== | ||
Habitat; symbiosis; biogeochemical significance; contributions to environment.< | Habitat; symbiosis; biogeochemical significance; contributions to environment.<be> | ||
G. sanguinis has been found to colonize the skin, mucosal surfaces (i.e. the lungs), blood, and urinary tract of humans. It is often part of the typical skin and mucosal microbiota but can become pathogenic if able to enter and colonize the bloodstream or other areas of the body. However, the chances of infection for most people are low, as it is a rare, opportunistic pathogen with small case numbers. Most cases are found in those who are immunocompromised and more susceptible to infection. G. sanguinis can cause various diseases and symptoms based on where it was able to colonize. For example, if the bacterium can colonize the mucosal membrane of the lungs, it can cause meningitis; if it is able to colonize the urinary tract, it can cause a urinary tract infection (UTI). | |||
Although this is primarily a human pathogen, there have been few documented animal cases. The first documented case of G. sanguinis being associated with animal disease was published in 2000. This study found meningoencephalitis associated with G. sanguinis infection in lambs. | |||
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.<br><br> | If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.<br><br> | ||
Revision as of 01:15, 22 November 2024
Classification
Domain; Phylum; Class; Order; family [Others may be used. Use NCBI link to find]
Species
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NCBI: [1] |
Genus species
Description and Significance
G. sanguinis is cocci shaped. Its cellular arrangement consists of pairs and short chains. G. sanguinis thrive in the human body. It is a pathogen that causes infection within the bloodstream, central nervous system, and the urinary tract. It is important to conduct research and expand our knowledge of G. sanguinis because it is a pathogen that is difficult to identify phenotypically. It is becoming more prevalent within different diseases in the body.
Genome Structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
Cell Structure, Metabolism and Life Cycle
Cell structure of Globicatella sanguinis (G. sanguinis) is a gram-positive bacteria. G. sanguinis metabolizes through peptide catabolic energy, active glycolytic, and heterolactic fermentation. G. sanguinis grow anaerobically and are also alpha-hemolytic, meaning that they have the ability to break down red blood cells. G. sanguinis is catalase negative.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.<be> G. sanguinis has been found to colonize the skin, mucosal surfaces (i.e. the lungs), blood, and urinary tract of humans. It is often part of the typical skin and mucosal microbiota but can become pathogenic if able to enter and colonize the bloodstream or other areas of the body. However, the chances of infection for most people are low, as it is a rare, opportunistic pathogen with small case numbers. Most cases are found in those who are immunocompromised and more susceptible to infection. G. sanguinis can cause various diseases and symptoms based on where it was able to colonize. For example, if the bacterium can colonize the mucosal membrane of the lungs, it can cause meningitis; if it is able to colonize the urinary tract, it can cause a urinary tract infection (UTI). Although this is primarily a human pathogen, there have been few documented animal cases. The first documented case of G. sanguinis being associated with animal disease was published in 2000. This study found meningoencephalitis associated with G. sanguinis infection in lambs.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
Symptoms of infection:
-meningeoencephalitis
References
Miller, A. O., Buckwalter, S. P., Henry, M. W., Wu, F., Maloney, K. F., Abraham, B. K., Hartman, B. J., Brause, B. D., Whittier, S., Walsh, T. J., & Schuetz, A. N. (2017). Globicatella sanguinis Osteomyelitis and Bacteremia: Review of an Emerging Human Pathogen with an Expanding Spectrum of Disease. Open forum infectious diseases, 4(1), ofw277. https://doi.org/10.1093/ofid/ofw277
Shewmaker PLSteigerwalt AG, Shealey L, Weyant R, Facklam RR.2001.DNA Relatedness, Phenotypic Characteristics, and Antimicrobial Susceptibilities of Globicatella sanguinis Strains. J Clin Microbiol39:.https://doi.org/10.1128/JCM.39.11.4052-4057.2001
Vela, A I et al. “Meningoencephalitis associated with Globicatella sanguinis infection in lambs.” Journal of clinical microbiology vol. 38,11 (2000): 4254-5. doi:10.1128/JCM.38.11.4254-4255.2000
1. Yu Y, Tsitrin T, Bekele S, et al. Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial Urethral Catheter Biofilms Examined in Longitudinal Profiles at the Proteomic Level. Biochemistry Insights. 2019;12. doi:10.1177/1178626419875089
Author
Page authored by Adisen Ames, Caleb Barker, Tasnim Goubar, & Samantha Kopyar, students of Prof. Bradley Tolar at UNC Wilmington.
