Myceliophthora thermophila: Difference between revisions
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==Description and significance== | ==Description and significance== | ||
<I> Myceliophthora</I> <I>thermophile</I> is an eukaryotic microbe, a mold, which is usually extracted from soil or self-heated cmoposts [2,3,4]. <I>M.</I> <I>thermophila</I> produces phyriform (pear shaped) conidia that measure between 3.0 and 4.5 μ. The conidia start off smooth and white and when they are mature, they are a dark brown color with a rough surface [3]. thermophiles grow optimally at high temperatures. This microbe grows optimally between 45-5 C°[2]. <I>M.</I> <I>thermophila</I> is a thermophilic phaeoid mold that is found in wood, straw and cmopost made of animal excrements in agricultural settings, such as farms [2]. It has been found to cause rare ifnections in humans that are hard to treat due to its resistance to standard antifungal medications and its ability to withstand high temperatures and pH levels [3]. | <I> Myceliophthora</I> <I>thermophile</I> is an eukaryotic microbe, a mold, which is usually extracted from soil or self-heated cmoposts [2,3,4]. <I>M.</I> <I>thermophila</I> produces phyriform (pear shaped) [http://en.wikipedia.org/wiki/Conidium conidia] that measure between 3.0 and 4.5 μ. The conidia start off smooth and white and when they are mature, they are a dark brown color with a rough surface [3]. thermophiles grow optimally at high temperatures. This microbe grows optimally between 45-5 C°[2]. <I>M.</I> <I>thermophila</I> is a thermophilic phaeoid mold that is found in wood, straw and cmopost made of animal excrements in agricultural settings, such as farms [2]. It has been found to cause rare ifnections in humans that are hard to treat due to its resistance to standard antifungal medications and its ability to withstand high temperatures and pH levels [3]. | ||
==Genome structure== | ==Genome structure== | ||
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==Metabolism== | ==Metabolism== | ||
It is a strick aerobe (cannot grow without the presence of oxygen) and is a L-lysine auxotroph [1]. | It is a strick aerobe (cannot grow without the presence of oxygen) and is a [http://en.wikipedia.org/wiki/Lysine L-lysine][http://en.wikipedia.org/wiki/Auxotrophy auxotroph] [1]. | ||
==Ecology== | ==Ecology== | ||
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==Pathology== | ==Pathology== | ||
<I>M.</I> <I>thermophila</I> has been the root cause of the rare, invasive human infection known as osteomyelitis [3,4]. It causes severe destructive osseous and cartilaginous infections that were untreatable by many antifungal agents [3]. Voriconazle, an antifungal medication used to treat serious infections, was prescribed to the patients after other antifungal medications were unsuccessful [3]. Infections occur after traumatic injuries in agricultrual areas [2,3,4]. | <I>M.</I> <I>thermophila</I> has been the root cause of the rare, invasive human infection known as [http://en.wikipedia.org/wiki/Osteomyelitis osteomyelitis] [3,4]. It causes severe destructive osseous and cartilaginous infections that were untreatable by many antifungal agents [3]. [http://en.wikipedia.org/wiki/Voriconazole Voriconazle], an antifungal medication used to treat serious infections, was prescribed to the patients after other antifungal medications were unsuccessful [3]. Infections occur after traumatic injuries in agricultrual areas [2,3,4]. | ||
Revision as of 18:24, 11 April 2013
A Microbial Biorealm page on the genus Myceliophthora thermophila
Classification
Higher order taxa
Domain (Eukaryota); Phylum (Ascomycota); Class (Sordariomycetes); Order (Sordariales); Family (Chaetomiaceae); Genus (Myceliophthora)
Species
Species (thermophila)
Myceliophthora thermophila
Description and significance
Myceliophthora thermophile is an eukaryotic microbe, a mold, which is usually extracted from soil or self-heated cmoposts [2,3,4]. M. thermophila produces phyriform (pear shaped) conidia that measure between 3.0 and 4.5 μ. The conidia start off smooth and white and when they are mature, they are a dark brown color with a rough surface [3]. thermophiles grow optimally at high temperatures. This microbe grows optimally between 45-5 C°[2]. M. thermophila is a thermophilic phaeoid mold that is found in wood, straw and cmopost made of animal excrements in agricultural settings, such as farms [2]. It has been found to cause rare ifnections in humans that are hard to treat due to its resistance to standard antifungal medications and its ability to withstand high temperatures and pH levels [3].
Genome structure
The genome for M. thermophila was released for the public on September 6, 2012 [1]. It was sequenced by the DOE Joint Genome Institute [1]. The total number of genes is 9,296, the total number of DNA bases is 38, 744,216 [1,4] on seven linear chromosomes[4]. There are 194 RNA genes present [4].
Cell and colony structure
M. thermophila is pyriform (pear shaped) conidia that meausre between 3.0 and 4.5μ [3]. They reproduce asexually and they grow on specialized stalks called conidiophores [2]. When the cell colonies are immature, it is white and looks almost like cotton. It then becmoes dark brown in color and rough when it matures [3].
Metabolism
It is a strick aerobe (cannot grow without the presence of oxygen) and is a L-lysineauxotroph [1].
Ecology
M. thermophila is isolated from soil and self-heated compost [2,4]. Strans of it has been found in the soil of North America, Europe Africa, and Asia[4]. It is also found in straw and animal compost [2,3]. Its ability to efficiently decompose straw allows it to grow on insoluble cellulose much like it grows on glucose[4]. This ability as well as the increased catalytic rates at high termperatures [2] would help promoste the development of bioproducts [4] and would help the development of advanced technologies fro derived fuels and chemical industries [2].
Pathology
M. thermophila has been the root cause of the rare, invasive human infection known as osteomyelitis [3,4]. It causes severe destructive osseous and cartilaginous infections that were untreatable by many antifungal agents [3]. Voriconazle, an antifungal medication used to treat serious infections, was prescribed to the patients after other antifungal medications were unsuccessful [3]. Infections occur after traumatic injuries in agricultrual areas [2,3,4].
References
[1] "Taxon Details Myceliophthora Thermophila ATCC42464." DOE Joint Genome Institute. The Regents of the University of California, Dec. 2012. http://img.jgi.doe.gov/cgi-bin/w/main.cgi?section=TaxonDetail&page=taxonDetail&taxon_oid=2517093045
[2] Bera, Grigoriev, RM. "Myceliophthora Thermophila." DOE Joint Genome Institue. The Regents of the University of California, 2013. http://genome.jgi-psf.org/Spoth2/Spoth2.home.html
[3] Chusid, Michael J. "Severe Osteomyelitis Caused by Myceliophthora Thermophila after a Pitchfork Injury." American Composite Manufacturer Association. Sept. 2006. http://www.ann-clinmicrob.com/content/5/1/21
[4] Berka, Grigoriev RM. "KEGG GENOME: Myceliophthora Thermophila." KEGG GENOME. Dec. 2012. http://www.genome.jp/kegg-bin/show_organism?org=mtm
Edited by Maura Mahoney, student of Dr. Lisa R. Moore, University of Southern Maine, Department of Biological Sciences, http://www.usm.maine.edu/bio
