Flavivirus NS1 protein: Difference between revisions
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==NS1 Expression, post translational processing and trafficking == | ==NS1 Expression, post translational processing and trafficking == | ||
[[Image:Alex Fig 3.jpeg|thumb|400px|left|Figure 3.Schematic summary of NS1 trafficking in mammalian cells. ]] | [[Image:Alex Fig 3.jpeg|thumb|400px|left|Figure 3.Schematic summary of NS1 trafficking in mammalian cells. (Muller and Young 2013) ]] | ||
Revision as of 04:36, 22 April 2014
Flavivirus
By Alex Gonzales
Flavivirus Structure
Figure 1. Flavivirus Structure. (A) Schematic representation of a flavivirus particle. Left: immature virion; right: mature virion. The unstructured spherical capsid contains the positive-stranded genomic RNA and multiple copies of the capsid protein C. Immature virions are covered by spiky complexes of 60 trimers of prM-E heterodimers. The proteolytic cleavage of prM results in the reorganization of the E proteins and the formation of smooth-surfaced particles covered with 90 E dimers. sE: soluble form of E that lacks the membrane anchor and an adjacent sequence element called ‘stem’. M: Membrane-associated cleavage product of prM. (B) Herringbone-like arrangement of90 E protein dimers at the virion surface as determined by cryo-electron microscopy .
NS1 Structure
Figure 2. NS1 dimer structure. (A) NS1 dimer with one subunit in gray andthe other colored by domain (blue, b roll; yellow, wing with orange connectorsubdomain; red, central b ladder). Disulfides are shown as yellow spheresand N-linked glycosylation sites as black sticks. A 20-residue disordered regions indicated with dotted lines. C, C terminus; N, N terminus.(Akey et al 2014).
