CTXφ Bacteriophage

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Overview

Figure 1: Filamentous phage(s) under an electron microscope (left), an artist's rendition, and some computer-generated models of varying proteins found in the head, neck, and tail fibers.[1] From Gagic D. et al.
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2016.00429/full

The CTXφ bacteriophage (or CTXphi bacteriophage) is a lysogenic, filamentous, single-stranded DNA phage that is responsible for turning the previously non-infectious Vibrio cholerae into a highly pathogenic microbe that causes disease in humans.[2],[3]

Genetic Material

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Infection, Replication & Lysing of Host Cell

Colony of Marburg virus. Transmission electron microscope image taken by Dr. Tom Geisbert
Figure 2: The life cycle of the CTXφ Bacteriophage with Vibrio cholerae as its host.
Link: wordpress.com/2020/04/25/a-bacteriophage-makes-v-cholera-a-killerbug/


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Filename: PHIL_1181_lores.jpg
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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CT & non-CT Toxins

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Conclusion

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References

  1. ↑ Gagic, D., Ciric M., Wen W., Ng F., Rakonjac J. (2016). "Exploring the Secretomes of Microbes and Microbial Communities Using Filamentous Phage Display." Frontiers in Microbiology, 7:429. https://doi.org/10.3389/fmicb.2016.00429.
  2. ↑ Davis, B. M., Kimsey, H. H., Chang, W., & Waldor, M. K. (1999). "The Vibrio cholerae O139 Calcutta bacteriophage CTXφ is infectious and encodes a novel repressor." Journal of Bacteriology, 181(21), 6779-6787.
  3. ↑ Ochman, H., Lawrence, J. & Groisman, E. (2000). "Lateral gene transfer and the nature of bacterial innovation." Nature, 405, 299–304. https://doi.org/10.1038/35012500.


Edited by Tara Cerny, student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2019, Kenyon College.

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