Jocelyn Xanthopoulo,
Bench B, 43922510,
31/08/2016
[1]
Classification
Higher order taxa
Bacteria; Fibrobactere-Chlorobi-Bacteroidetes superphylum; Bacteroidetes; Bacteroidales; Porphyromonadaceae; Porphyromonas
Species
Species name: Porphyromonas gingivalis
Type Strain: W83
Description and significance
Give a general description of the species (e.g. where/when was it first discovered, where is it commonly found, has it been cultured, functional role, type of bacterium [Gram+/-], morphology, etc.) and explain why it is important to study this microorganism. Examples of citations [1], [2]
Genome structure
Select a strain for which genome information (e.g. size, plasmids, distinct genes, etc.) is available.
Cell structure and metabolism
Cell wall, biofilm formation, motility, metabolic functions.
Ecology
Aerobe/anaerobe, habitat (location in the oral cavity, potential other environments) and microbe/host interactions.
Pathology
Do these microorganisms cause disease in the oral cavity or elsewhere?
Application to biotechnology
Bioengineering, biotechnologically relevant enzyme/compound production, drug targets,…
Current research
Summarise some of the most recent discoveries regarding this species.
References
References examples
1. Nelson, K.E., Fleischmann, R.D., DeBoy, R.T., Paulsen, I.T. (2003) Complete Genome Sequence of the Oral Pathogenic Bacterium Porphyromonas gingivalis Strain W83. J Bacteriol 185:591-601.
2. Loos, B.G., Dyer, D.W., Whittam, T.S., Selander, R.K. (1993) Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect Immun 61:204-212.
3. Haffajee, A.D., Cugini, M.A., Tanner, A., Pollack, R.P., Smith, C., Kent, R.L., Socransky, S.S. (1998) Subgingival microbiota in healthy, well-maintained elder and periodontitis subjects. J Clin Periodontol5:346-353.
4. Pederson, E.D., Turner, D.W., Lamberts, B.L., Schade, S.Z. (1997) Reducing medium for the cultivation of Porphyromonas gingivalis. Microbios 89:119-124.
5. Butler, C.A., Dashper, S.G., Zhang, L., Seers, C.A., Mitchell, H.A. (2014) The Porphyromonas gingivalis Ferric Uptake regulator orthologue binds hemin and regulates hemin-responsive biofilm development. PLOS One 5:e28451
6. How, K.Y., Song, K.P., Chan, K.G. (2016) Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Front Microbiol 7:53.
7. Petersen, P. E., Ogawa, H. (2012) The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontology 2000:15-39.
8. Hendrickson, E.L., Xia, Q., Wang, T., Lamont, R.J., Hackett, M. (2009) Pathway analysis for intracellular Porphyromonas gingivalis using a strain ATCC 33277 specific database. BMC Microbiol 9:185.
9. Tribble, G.D., Kerr, J.D., Wang, B. (2014) Genetic diversity in the oral pathogen Porphyromonas gingivalis: molecular mechanisms and biological consequences. Future Microbiol 8:102-112.
10. Lewis, J.P., Dawson, J.A., Hannis, J.C., Muddiman, D., Macrina, F.L. (1999) Hemoglobinase Activity of the Lysine Gingipain Protease (Kgp) of Porphyromonas gingivalis W83. J Bacteriol 181:405-413.
11. Sakanaka,A., Takeuchi,H., Kuboniwa, M., Amano, A. (2016) Dual lifestyle of Porphyromonas gingivalis in biofilm and gingival cells. Microb Pathog 94:42-47.
12. Zhu, Y., Dashper, S.G., Chen, Y., Crawford, S., Lakeski, N., Reynolds, E.C. (2013) Porphyromonas gingivalis and Treponema denticola Synergistic Polymicrobial Biofilm Development. Plos One 8:e71727.
13. Griffen, A.L., Becker, M.R., Lyons, S.R., Moeschberger, M.L., Leys, E.J. (1998) Prevalence of Porphyromonas gingivalis and Periodontal Health Status. J Clinical Microbiol 36:3239-3242.
14. Park, Y., Yilmaz, O., Jung, I., Lamont, L.J. (2004) Identification of Porphyromonas gingivalis Genes Specifically Expressed in Human Gingival Epithelial Cells by Using Differential Display Reverse Transcription-PCR. Infect Immun 72:3752-3758.
This page is written by Jocelyn Xanthopoulo for the MICR3004 course, Semester 2, 2016
