Bacteriophages in Cancer Biology and Treatment
Section
By Salome Shubitidze!
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC. Every image requires a link to the source.
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The use of Bacteriophages for drug delivery
Chemotherapy drugs, while shown to have anti-tumor effects, tend to result in severe toxicity and widespread distribution throughout the body: notably damaging healthy and malignant cells. New research has started to focus on using bacteriophages as an individualized drug-carrying anti-cancer therapy. The therapy would be targeted, based on genetically-modifying and chemically manipulating filamentous bacteriophages. In Bar et al. 2008, the phages were modified to display a host-specificity-conferring ligand, and carry a cytotoxic drug by chemical conjugation
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Changing the Tumor Microenvironment
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Phage Display Methods and Tumor-specific Antibody–receptor Pairs
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Activating the Innate Immune System
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Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2018, Kenyon College.