Schizosaccharomyces pombe
A Microbial Biorealm page on the genus Schizosaccharomyces pombe
Classification
Higher order taxa
Superkingdom: Eukaryota
Kingdom: Fungi
Phylum: Ascomycota
Subphylum: Dikarya
Subphylum: Taphrinomycotina
Class: Schizosaccharomycetes
Order: Schizosaccharomycetales
Family: Schizosaccharomycetaceae
Genus: Schizosaccharomyces
Species
Schizosaccharomyces pombe
Also known as: Schizosaccharomyces malidevorans
Description and significance
The fission yeast Schizosaccharomyces pombe is a unicellular eukaryote that is rod shaped. They measure approximately 2 to 3 microns in diameter and 7 to 14 microns in length (1). S. pombe is usually found in sugar-containing fermentations of alcohol from the subtropical regions (2).
Even though its origin dates back to quite a long time ago, it was not widely known before the 1890’s. It was discovered in 1893 when a group working in a Brewery Association Laboratory in Germany was looking at sediment found in millet beer imported from East Africa that gave it an unsavory acidic taste (1). P. Lindner was the first to describe Schizosaccharomyces pombe. He chose as its epithet the Swahili word for beer, pombe (2). It was identified as yeast, and it became known as the fission yeast because it reproduces by means of fission unlike its relative Saccharomyces. The name Schizosaccharomyces was assigned to it because Schizo- means “different,” which had been previously used to describe other fission species.
The sequencing of its genome was significant since S. pombe is a single-celled living archiascomycete fungus that shares many features with cells of more complicated eukaryotes (3). Researchers have identified fifty genes of S. pombe associated with human diseases including cystic fibrosis, hereditary deafness, and diabetes (3). Researchers state that the largest group of human disease-related genes are those implicated in cancer. There are 23 such genes, and they are involved in DNA damage and repair, checkpoint controls, and the cell cycle. All these processes are involved with maintaining genomic stability (3). These discoveries are important because it will allow researchers to find out more about the evolution of one-celled and multi-celled eukaryotic organisms compared to others such as bacteria, which do not have nucleated cells. Further analyses and comparisons should reveal which genes define eukaryotic cells and the transition from one-celled to multi-celled organisms (3).
Genome structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?
Cell structure and metabolism
Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.
Ecology
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Pathology
How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
Application to Biotechnology
Does this organism produce any useful compounds or enzymes? What are they and how are they used?
Current Research
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References
Edited by student of Rachel Larsen
