Crohn’s Disease Relating to the Gut Microbiota Specifically Faecalibacterium prausnitzii

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Introduction

Magnified 20,000X, this colorized scanning electron micrograph (SEM) depicts a grouping of methicillin resistant Staphylococcus aureus (MRSA) bacteria. See PHIL 617 for a black and white view of this image. Phoro credit: CDC.

By Kayla Arone

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Background

Include some current research, with at least one figure showing data.

Propionibacterium acnes is a gram-positive, fairly slow-growing aerotolerant bacterium. This bacteria is typically linked to the skin condition acne vulgris, commonly known as skin acne. This species is daily commensal and highly present on healthy skin epithelium. Little is detected on the skin of adolescents, specifically those pre-pubescent. This bacterium lives on fatty acids in sebum secreted by hair sebaceous glands in hair follicles. It can also be found in the gastrointestinal biome.

Section 2

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Microbial Remediation of Crohn’s Disease

Include some current research, with at least one figure showing data.

Limitations and Future Research

Conclusion

Research proves the connection between the human gut microbial community and Crohn’s Disease. There is less literature on the link between, F. prausnitzii,, but enough is present to continue to research the correlation between the two on further research on the topic. Crohn’s Disease is a non-treatable illness that causes significant interferance in the lives of those inflicted with it, and to move forward with trying to work to create a treatment, the factors contributing to the disease need to be understood. The effect of F. prausnitzii, on the gut-brain axis initially demonstrates the formation of this relationship with the overlap in F. prausnitzii, affecting other IBD patients. In short, the dysregulation of gut microbiota affects humans well being and Crohn’s disease is one that it causes to come to fruition. With all of this information, we can look into more possible clinical trials. Further research is needed to reach these steps, but as more is learned and developed about the connection between the gut-microbiota F. prausnitzii, and Crohn’s disease, many scientific discoveries can be created.

References

  1. ↑ 1.0 1.1 Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
  2. ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski,at Kenyon College,2024

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