Anti-Helicobacter Pylori Activity From Natural Products

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A hematoxylin and eosin stain of Helicobacter pylori in the lumen of a gastric foveola. Photo by Ed Uthman¹

For many individuals, Helicobacter pylori, gram-negative bacteria, reside in the stomach that many times lead to duodenal and peptic ulcers. Even though most individuals infected with H. pylori never show symptoms, this bacterium causes around 85 percent of all ulcers. Antibiotics, clarithromycin and amoxicillin, and a proton pump inhibitor are typically used to inhibit H. pylori growth to cure the ulcer. This triple therapy for the elimination of H. pylori faces uprising resistance problems demanding new antibiotic candidates. Alternative therapies from natural plants and foods are gaining popularity in order to find products to help combat the drug-resistant strands. Many studies have examined the antimicrobial activity of Pakistanian, Indian, and Iranian medicinal plants can be used as potential bactericidal agents for curing ulcers. Additionally, studies have found that fractional isolates of honey and turmeric are responsible for antibacterial activity. These compounds provide new lead molecules that can help eradicate H. pylori.

Bactericidal Activity of Plant Extracts

Many different extracts from plants have been shown to have antimicrobial activity. GutGard™ is a flavonoid rich extract of Glycyrrhiza glabra Linn, which is commonly known as Licorice. The company sells this product to those who suffer from gut and digestion related issues. Many studies have been conducted to determine the validity of GutGard™. Furthermore, different acetone and methanol extracts were taken from traditional medicinal plants to determine the minimal inhibitory concentration on different strands of H. pylori.

Flavonoid Extract

Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.

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Filename: Ebola virus 1.jpeg
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Overall paper length should be 3,000 words, with at least 3 figures with data.

Bactericidal Activity of Natural Foods

Include some current research in each topic, with at least one figure showing data.

Further Reading

[Sample link] Ebola Hemorrhagic Fever—Centers for Disease Control and Prevention, Special Pathogens Branch

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by (your name here), a student of Nora Sullivan in BIOL168L (Microbiology) in The Keck Science Department of the Claremont Colleges Spring 2014.