Bacteriophages in Cancer Biology and Treatment: Difference between revisions
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polarized. M2- polarized macrophages function to repair damaged tissues, and aid the final phase of inflammation repair. They have been found to suppress tumor-specific T cell activation and proliferation. Presence of TAMS in and around a tumor microenvironment is correlated with a poor prognosis for those suffering from melanoma or breast cancer. | polarized. M2- polarized macrophages function to repair damaged tissues, and aid the final phase of inflammation repair. They have been found to suppress tumor-specific T cell activation and proliferation. Presence of TAMS in and around a tumor microenvironment is correlated with a poor prognosis for those suffering from melanoma or breast cancer. | ||
Recently, bacteriophages have been show to be capable of modifying the tumor environment. Phage coat proteins, and phage DNA tend to elicit strong responses from the innate immune system, prompting phagocytosis and cytokine release. Delivering phages into the tumor microenvironment has been demonstrated to initiate infiltration of tumor-associated macrophages. Eriksson et al. 2009 found that the microenvironment of bacteriophage-treated tumors switched from M2-polarized to a more M1-polarized environment post phage treatment. The study found the administration of bacteriophages lead to an increase of neutrophilic granulocytes around the site of cancer (1). | Recently, bacteriophages have been show to be capable of modifying the tumor environment. Phage coat proteins, and phage DNA tend to elicit strong responses from the innate immune system, prompting phagocytosis and cytokine release. Delivering phages into the tumor microenvironment has been demonstrated to initiate infiltration of tumor-associated macrophages. Eriksson et al. 2009 found that the microenvironment of bacteriophage-treated tumors switched from M2-polarized to a more M1-polarized environment post phage treatment. The study found the administration of bacteriophages lead to an increase of neutrophilic granulocytes around the site of cancer (1). <ref> name=c> Clokie M, Kropinski A. Bacteriophages. Methodsand Protocols, 1: Isolation, Characterization and Interac-tions. Humana Press, 2009: 54–75. </ref> | ||
Evidence from Gambashidze et al. 2012 has shown that combining E.coli phagelysate and chemotherapy inhibits the rate of cancer growth three fold compared to tumors left untreated. The combined cancer therapy was more potent than chemotherapy and phagelysate administered alone. The study showed that injected doses of phagelysates did not lead to malignant growth, and was accepted in mice (2). | Evidence from Gambashidze et al. 2012 has shown that combining E.coli phagelysate and chemotherapy inhibits the rate of cancer growth three fold compared to tumors left untreated. The combined cancer therapy was more potent than chemotherapy and phagelysate administered alone. The study showed that injected doses of phagelysates did not lead to malignant growth, and was accepted in mice (2). | ||
Revision as of 18:41, 14 May 2020
Section
By Salome Shubitidze!
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC. Every image requires a link to the source.
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Evidence from Gambashidze et al. 2012 has shown that combining E.coli phagelysate and chemotherapy inhibits the rate of cancer growth three fold compared to tumors left untreated. The combined cancer therapy was more potent than chemotherapy and phagelysate administered alone. The study showed that injected doses of phagelysates did not lead to malignant growth, and was accepted in mice (2).
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Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2018, Kenyon College.
