Deamination model of hypermutation

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Contents 1 Introduction 2 Section 1 Mechanism 3 Section 2 Regulation 4 Conclusion 5 References

Introduction Deamination is a proposed mechanism of somatic hypermutation(SHM) which results in point mutations within the Immunoglobulin variable region(IgV) gene. Deamination involves the use of activation-induced deaminase(AID), a protein which converts cytidine(cytosine bound to ribose) to uridine(uracil bound to ribose) which initiates DNA repair. In this case, B cells use error prone DNA repair mechanisms resulting in a sustained point mutation. These mutations code for a varying expression of the IgV gene resulting in an antibody with either a higher or lower binding affinity. After hypermutation, higher binding affinity is selected for during affinity maturation resulting in a more effective antibody.

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Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.[1].

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References

Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
Lee G, Low RI, Amsterdam EA, Demaria AN, Huber PW, Mason DT. Hemodynamic effects of morphine and nalbuphine in acute myocardial infarction. Clinical Pharmacology & Therapeutics. 1981 May;29(5):576-81.

Edited by Luke Smallwood, student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2020, Kenyon College.