Free Fatty Acids as antibacterial agents against several super pathogens including MRSA

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Introduction

Scanning electron micrograph of Methicillin-resistant Staphylococcus aureus (MRSA), USA300 strain, being engulfed by a human neutrophil. From NIH.

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Introduce the topic of your paper. State your health service question, and explain the biomedical issues.

About Free Fatty Acids

Include some current research, with at least one figure showing data.

Carbohydrate fatty acid derivatives that have antibacterial qualities towards S. aureus, excluding compound 4, which has its hydroxyl group in the wrong orientation. [1].

History of Fatty Acids as Antimicrobial Agents

Include some current research, with at least one figure showing data.

Transmission electron microscopy showing the morphology of S. aureus after 2 hour killing assay in the absence (A) or presence (B) of 5 µg/ml sapienic acid. The arrows show aberrant septation events. [2].

Bactericidal Effects of Fatty Acids on Methicillin Resistant and Susceptible Staphylococcus aureus

Include some current research, with at least one figure showing data.

Sapienic acid (C-6-H) used to treat S. aureus in mice. "(A) Impact on S. aureus cfu in kidneys of infected mice by injection of C-6-H (n = 10) or PBS (n = 9), mice were inoculated with 2.5 3 107 cfu. (B) IL-6 production in S. aureus infected mice treated with C-6-H (n = 9) or PBS (n = 9). (C) Effect of C-6-H (n = 20) or PBS (n = 19) on S. aureus cfu in a chronic dermatitis with superimposed infection model. *p < 0.0002, **p < 0.0001, ***p < 0.03 by Student’s t test. Dashed lines represent mean values." [3].

References

[1] Wikimedia. NIH.

[2] Clarke, S.R., Mohamed, R., Bian, L. et al. The Staphylococcus aureus Surface Protein IsdA Mediates Resistance to Innate Defenses of Human Skin. (2007) Cell Host & Microbe, 1(3): 199-212

Authored for BIOL 291.00 Health Service and Biomedical Analysis, taught by Joan Slonczewski, 2016, Kenyon College.