HPV Virology and Treatment

From MicrobeWiki, the student-edited microbiology resource

Introduction

HPV currently infects twenty million Americans and about another six million become infected each year. Today, at least fifty percent of sexually active men and women get HPV during their lifetime (40). As one can see, this sexually transmitted disease is among the most prevalent in America, which explains the importance of understand the disease. Human papillomavirus (HPV) or the “wart virus” is a virus belonging to its own family, papillomaviridae. There are more than a 100 types of HPV and as reflected in its name, species specific for humans. There are two types, cutaneous or mucocutaneous, based upon its tissue tropism or predilection for infecting specific areas of the human body. Human papillomavirus infections are diagnosed worldwide, account for the most common sexually transmitted disease worldwide, and have been associated with both cutaneous and mucocutaneous cancers prompting attempts to prevent infections using vaccines. In short, it has become a global health infection warranting every effort to control and eradicate it.


Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.


To upload an image: Use "Upload File" (in margin at left)
To make the image appear, you need to embed image insertion code (see sample at right). The insertion code consists of:
Double brackets: [[
Filename: PHIL_1181_lores.jpg
Thumbnail status: |thumb|
Pixel size: |300px|
Placement on page: |right|
Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
Closed double brackets: ]]

Other examples:
Bold
Italic
Subscript: H2O
Superscript: Fe3+

Sample Section 2


Include some current research in each section.

Sample Section 3


Include some current research in each section.

Conclusion


Overall paper length should be approximately 2,000 to 2,500 words.
Include at least two data figures.
Use professional sources, including at least two research studies. Public Health Measures Against HPV

References

General reviews:

Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Disease. 7th Ed. 2009. Churchill Livingstone, Philadelphia. V.2. Chapter 144: Papillomaviruses. Section Eds. William Bounez and Richard C. Reichman.

Wheeler, CM. Natural history of human papillomavirus infections, cytologic and histologic abnormalities, and cancer. Obstr Gynecol Clin. 35 (4) Dec 2008; pp.519-536.

Citations: 1) Tilston, P. Anal human papillomavirus and anal cancer. J Clin Pathol 1997; 50:625. 2) Yang, R, Yutzy, WH 4th, Viscidi, RP,Roden RB. Interaction of L2 with beta-actin directs intracellular transport of papillomavirus and infection. J Biol Chem 2003; 278:12546. 3) Yang, R, Day, PM, Yutzy, WH 4th, et al. Cell surface-binding motifs of L2 that facilitate papillomavirus infection. J Virol 2003; 77:3531. 4) Johnson, KM, Kines, RC, Roberts, JN, et al. Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus. J Virol 2009; 83:2067. 5) Selinka, HC, Florin, L, Patel, HD, et al. Inhibition of transfer to secondary receptors by heparan sulfate-binding drug or antibody induces noninfectious uptake of human papillomavirus. J Virol 2007; 81:10970. 6) Shafti-Keramat, S, Handisurya, A, Kriehuber, E, et al. Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses. J Virol 2003; 77:13125. 7) Doorbar, J. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond)2006; 110:525. 8) Bosch, FX, Manos, MM, Munoz, N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group. J Natl Cancer Inst 2001; 93:315. 9) Zaki, SR, Judd, R, Coffield, LM, et al. Human papillomavirus infection and anal carcinoma. Retropsective analysis by in-situ hybridization and the polymerase chain reaction. Am J Pathol 1992;140:1345. 10) Frisch, M, Glimelius, B, van den Brule, et al. Sexually transmitted infection as a cause of anal cancer. N Engl J Med 1997; 337:1350. 11) Zur Hausen, H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 2000; 92:690. 12) Schlegel, R. Papillomaviruses and human cancer. Semin Virol 1990; 1:297. 13) Vogelstein, B, Fearon, ER, Kern SE, et al. Allelotype of colorectal carcinomas. Science 1989; 244: 207. 14) Masuda, H, Miller, C, Koeffler, HP, et al. Rearrangement of the p53 gene in human osteogenic sarcoma. Proc Natl Acad Sci USA 1987; 84:7716. 15) Hinds, P, Finlay, C, Levine, AJ. Mutilation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol 1989; 63:739. 16) Dupuy, C, Buzoni-Gatel, D, Touze, A, et al. Cell mediated immunity induced in mice by HPV 16 L1 virus like particles. Microb Pathog 1997; 22:219. 17) Puthenveettil, JA, Frederickson, SM, Reznikoff, CA. Apoptosis in human papillomavirus 16 E7-, but not E6-immortalized human uroepithelial cells. Oncogene 1996; 13:1123. 18) Magal, SS, Jackman, A, Pei, XF, et al. Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins. Int J Cancer 1998; 75:96. 19) Lorincz, AT. Molecular methods for the detection of human papillomavirus infection. Obstet Gynecol Clin North Am 1996; 23:707. 20) De Sanjose, S, Diaz, M, Castellsague, X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007; 7:453. 21) Wright, TC Jr, Schiffman, M. Adding a test for human papillomavirus DNA to cervical-cancer screening. N Engl J Med 2003: 348:489. 22) Clifford, GM, Gallus, S, Herrero, R, et al. Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet 2005; 366: 991. 23) Workowski, KA, Berman, SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 2006; 55:1. 24) Winer, RL, Feng, Q, Hughes, JP, et al. Risk of female human papillomavirus acquisition associated with first male sex partner. J Infect Dis 2008; 197: 297. 25) Shvetsov, YB, Hernandez, BY, McDuffie, K, et al. Duration and clearance of anal human papilloavirus (HPV) infection among women: the Hawaii HPV cohort study. Clin Infect Dis 2009; 48:536. 26) Goodman, MT, Shvetsov, SB, McDuffie, K, et al. Acquisition of anal human papillomavirus (HPV) infection in women: the Hawaii HPV Cohort Study. J Infect Dis 2008; 197:957. 27) Baldwin, SB, Wallace, DR, Papenfuss, MR, et al. Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic. Sex Transm Dis 2004; 31:601. 28) Castellsague, X, Bosch, F, Munoz, N, et al. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N Engl J Med 2002; 346: 1105. 29) Guiliano, AR, Lu, B, Nielson, CM, et al. Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. J Infect Dis 2009; 199:1. 30) Lu, B, Wu, Y, Nielson, CM, et al. Factors associated with acquisition and clearance of human papillomavirus infection in a cohort of US men: a prospective study. J Infect Dis 2009; 199:362. 31) Allen, AL, Siegfried, EC. What’s new in human papillomavirus infection. Curr Opin Pediatr 2000; 12:365. 32) Beutner, KR. Nongenital human papillomavirus infections. Clin Lab Med 2000; 20:423. 33) Koutsky, L. Epidemiology of genital human papillomavirus infection. Am J Med 1997; 102:3. 34) Kjaer, SK, Tran, TN, Sparen, P, et al. The burden of genital warts: a study of nearly 70,000 women from the general female population in the 4 Nordic countries. J Infect Dis 2007; 196:1447. 35) Franco, EL, Duarte-Franco, E, Ferenczy, A. Cervical cancer: epidemiology, prevention, and the role of human papillomavirus infection. CMAJ 2001; 164:1017. 36) Petersen, BL, Buchwald, C, Gerstoft, J, et al. An aggressive and invasive growth of juvenile papillomas involving the total respiratory tract. J Laryngol Otol 1998; 112:1101. 37) Sterling, JC, Handfield-Jones, S, Hudson, PM. Guidelines for the management of cutaneous warts. Br J Dermatol 2001; 144:4. 38) Auborn, KJ, Carter, TH. Treatment of human papillomavirus gynecologic infections. Clin Lab Med 2000; 20: 407. 39) Steinbrook, R. The potential of human papillomavirus vaccines. N Engl J Med 2006; 354:1109. 40) "STD Facts- Human Papillomavirus." Center for Disease Control and Prevention. Center for Disease Control and Prevention, Apr. 2008. Web. 19 Nov. 2009. <http://www.cdc.gov/std/HPV/STDFact-HPV.htm>.