Hendra Virus

This is a curated page. Report corrections to Microbewiki.

Etiology/Bacteriology

Taxonomy

| Order = Monoegavirales |Family = [[Paramyxoviridae]] |Genus = [[Henipavirus]] |Species = Hendra Virus
|NCBI: Taxonomy Genome: Genome|}

Description

Hendra Virus is a member of the Paramyxoviridae virus family, which also includes the Measles virus, Canine Distemper virus, and Mumps virus. [3] It shares the genus Henipavirus with Nipah virus. [3] Hendra virus first broke out in 1994 at a stable in Hendra, a town in Queensland, Australia. In this initial outbreak, the virus killed 13 horses and infected two humans, killing one. [4] There have been several outbreaks of Hendra since then, all concentrated in Queensland and New South Wales in Australia.[5] Flying foxes are believed to be the reservoir of Hendra virus, based on the detection of Hendra virus antibodies in the blood of several flying fox species and the discovery of a Hendra-like virus in a healthy flying fox. [6] Hendra Virus has been documented to affect horses and humans. In horses, an infection is generally characterized by depression, fever, and a frothy discharge from the nose. [4] In humans, flu-like symptoms occur, but the disease has been reported to progress to encephalitis in some fatal cases. [7]

Pathogenesis

Transmission

Flying foxes, bats from the genus Pteropus are considered to be the reservoir hosts of Hendra virus. This is due to to the detection of Hendra virus antibodies in Black flying foxes (Pteropus alecto), grey-headed flying foxes (Pteropus poliocephalus), little red flying foxes (Pteropus scapulatus), and spectacled flying foxes (Pteropus conspicillatus) in 1995.[6] This was further confirmed by the isolation of a Hendra-like virus from a healthy grey-headed flying fox. [6] Typically, transmission between infected flying foxes and horses happens first. The mechanism of transmission is still not completely clear, but several hypotheses have been proposed. In the most plausible, horses become infected by eating pasture contaminated with flying fox foetal tissues or birthing fluids.[6] This hypothesis was proposed because many Hendra infections fall within the birthing period of flying foxes (August to October), and the virus has been isolated from uterine fluid, foetal liver, and foetal lung of flying foxes in 2000.[8,9] In another proposed theory, horses become infected with the virus when they eat pellets of masticated fibrous fruit discarded by flying foxes.[6] Once a horse become infected, transmission from horse to horse, and from horses to humans, occurs through close contact with infected body fluids and secretions. [9]

Infectious Dose and Viral Spread

Currently, the infectious dose of Hendra virus is not known.[10] However, it is clear that after acquisition of an infectious dose of virus, the Hendra virus appears to spread systematically through the body, focusing on the lymph nodes and respiratory system. In experimentally infected horses, Hendra virus was recovered from lymph nodes, lung, kidney, brain and cerebrospinal fluid, as well as being detected in nasal swabs, blood, urine, and feces. [10]. In the original 1994 epidemic, the virus was detected in the lung, liver, kidney and spleen of the human fatality. [11] Keep editing

Epidemiology

As of 2008, all of the Hendra virus outbreaks have occurred in Queensland and New South Wales in Australia.[5] By that point, 29 horses and 7 human cases have been documented. Spillovers of Hendra virus to humans occurs after prolonged contact with dead or dying infected horses and their body fluids. This is evident by the fact that 5 of the 7 confirmed cases were veterinarians or their assistants, who performed necropsies or invasive procedures on Hendra virus infected horses.[12] The remaining cases involved trainers or stable workers who interacted closely with the infected horses.[4]

Clinical Presentation

Incubation Period and Disease Progression

After contact with, inhalation or ingestion of contaminated body fluids and secretions, there is an incubation period of 7-8 days in humans

References

1.
2.
3. Wang LF, Yu M, Hansson E, Pritchard LI, Shiell B, Michalski WP, Eaton BT. 2000. The exceptionally large genome of Hendra virus: support for creation of a new genus within the family Paramyxoviridae. J Virol 74:9972–9979.
4. Murray K, Rogers R, Selvey L, Selleck P, Hyatt a., Gould a., Gleeson L, Hooper P, Westbury H. 1995. A novel morbillivirus pneumonia of horses and its transmission to humans. Emerg Infect Dis 1:31–33.
5. Playford EG, McCall B, Smith G, Slinko V, Allen G, Smith I, Moore F, Taylor C, Kung YH, Field H. 2010. Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008. Emerg Infect Dis 16:219–223.
6. Field H, Young P, Yob JM, Mills J, Hall L, Mackenzie J. 2001. The natural history of Hendra and Nipah viruses. Microbes Infect 3:307–314.
7. Marsh G a., Wang LF. 2012. Hendra and Nipah viruses: Why are they so deadly? Curr Opin Virol 2:242–247.
8. Haplin K, Young PL, Field HE, Mackenzie JS. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol. 2000 Aug;81(Pt 8):1927-32.
9. Hanna JN, McBride WJ, Brookes DL, Shield J, Taylor CT, Smith IL, Craig SB, Smith G. 2006. Hendra virus infection in a veterinarian. Med J Aust 185:562–564.
10. Marsh G a., Haining J, Hancock TJ, Robinson R, Foord AJ, Barr J a., Riddell S, Heine HG, White JR, Crameri G, Field HE, Wang LF, Middleton D. 2011. Experimental infection of horses with Hendra virus/Australia/horse/2008/Redlands. Emerg Infect Dis 17:2232–2238.
11. Paterson DL, Murray PK, McCormack JG. 1998. Zoonotic disease in Australia caused by a novel member of the paramyxoviridae. Clin Infect Dis 27:112–118.
12. Mendez DH, Judd J, Speare R. 2012. Unexpected result of Hendra virus outbreaks for veterinarians, Queensland, Australia. Emerg Infect Dis 18:83–85.