Talimogene Laherparepvec: A groundbreaking viral therapy for late stage melanoma

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Figure 1: Scatter plot representing the effect of Bifidobacterium longum subsp. infantis on intestinal epithelial cell viability. The study was done by O'Hara et al in 2006 [1].

By Alex Fazioli

Talimogene Laherparepvec (T-VEC) is an engineered Herpes simplex virus type 1 designed to specifically target, reproduce, and lyse human tumor cells [1]. T-VEC also produces granulocyte macrophage colony-stimulating factor (GM-CSF) to improve the antitumor immune response within the human body upon the lysis of tumor cells [1]. T-VEC avoids infecting non-cancerous cells by having all copies of two key neurovirulence factor genes deleted RL1 and US12 [2]. The deletion of the US12 gene puts its promoter in close proximity to the US11 increasing its expression which has been shown to increase the ability of T-VEC to replicate within tumour cells [3].

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Baltimore classification: dsDNA
Family: Herpesviridae
Virion: Enveloped
Capsid symmetry: Icosahedral
Replication site: Nucleus and cytoplasm

Section 2

Include some current research, with at least one figure showing data.

Section 3

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Section 4



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2018, Kenyon College.