The Acquisition, Metabolism, and Pathological Mechanisms Underlying Giardia Lamblia

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This is the leader section -- here you can write a short description of your topic and why it is interesting. The goal is for this to quickly cover the main ideas of your topic and get the reader interested in reading the rest!

Section 1

Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.


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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Pathomechanisms


Epithelial Barrier Dysfunction

G. lamblia is able to cause disease without penetrating the epithelium, invading tissues, or entering the bloodstream. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856818/)

Some patients have with chronic giardiasis have been found to have epithelial barrier dysfunction, which down regulates the tight junction protein claudin 1 (wikilink) and increases epithelial apoptosis (wikilink). This causes failure of sodium-dependent glucose absorption, which results in active chloride ion secretion. Water then enters the lumen (wikilink) and causes diarrhea. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856804/)


Section 3



Further Reading

[Sample link] Ebola Hemorrhagic Fever—Centers for Disease Control and Prevention, Special Pathogens Branch

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by (your name here), a student of Nora Sullivan in BIOL168L (Microbiology) in The Keck Science Department of the Claremont Colleges Spring 2014.