The Novel Microbiome of Centenarians
Section
By Liz DeProspo
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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC. Every image requires a link to the source.
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tag. A variety of factors contribute to this longevity, including a lack of genetically inherited disorders and beneficial diet and exercise choices earlier in life. Appropriate exercise and nutritional choices–as well as genetic differences, such as relative levels of growth factor present in adults–have been linked with ultimately determining an individual’s lifespan. However, another key biological factor has recently been linked to the medical resiliency of these long-lived individuals: their microbial gut composition. While aging is generally linked to a reduction in microbial diversity and ability to fight infection, analysis of the gut microbiome of centenarians has revealed trends in the relative abundance of specific consequential microbial species compared to the general population.
The Gut Microbiome and Immune Implications
Probiotic Upregulation of Memory
Bile Acid Pathways
Species Composition Changes Prior to Death
References
Sato, Y., Atarashi, K., Plichta, D.R. et al. Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature 599, 458–464 (2021). https://doi.org/10.1038/s41586-021-03832-5
- ↑ [Sato, Y., Atarashi, K., Plichta, D.R. et al. Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature 599, 458–464 (2021). https://doi.org/10.1038/s41586-021-03832-5]
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2023, Kenyon College