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[http://www.sciencemag.org/content/307/5714/1461.abstract Veneti, Zoe et al. "A Functional Dosage Compensation Complex Required for Male Killing in ''Drosophila''". ''Science''. 2005. Volume 307. p. 1461-1463.]
[http://www.sciencemag.org/content/307/5714/1461.abstract Veneti, Zoe et al. "A Functional Dosage Compensation Complex Required for Male Killing in ''Drosophila''". ''Science''. 2005. Volume 307. p. 1461-1463.]


[http://www.biomedcentral.com/1741-7007/5/9 Bentley, Joanna K et al. “The pathology of embryo death caused by the male-killing ''Spiroplasma'' bacterium in ''Drosophila nebulosa''”. ''BMC Biology''. Volume 5.]
[http://www.biomedcentral.com/1741-7007/5/9 Bentley, Joanna K et al. “The pathology of embryo death caused by the male-killing ''Spiroplasma'' bacterium in ''Drosophila nebulosa''”. ''BMC Biology''. 2007. Volume 5.]


Edited by Jennifer Martin, a student of [http://www.jsd.claremont.edu/faculty/profile.asp?FacultyID=254/ Nora Sullivan] in BIOL187S (Microbial Life) in [http://www.jsd.claremont.edu/ The Keck Science Department of the Claremont Colleges] Spring 2013.
Edited by Jennifer Martin, a student of [http://www.jsd.claremont.edu/faculty/profile.asp?FacultyID=254/ Nora Sullivan] in BIOL187S (Microbial Life) in [http://www.jsd.claremont.edu/ The Keck Science Department of the Claremont Colleges] Spring 2013.


<!--Do not edit or remove this line-->[[Category:Pages edited by students of Nora Sullivan at the Claremont Colleges]]
<!--Do not edit or remove this line-->[[Category:Pages edited by students of Nora Sullivan at the Claremont Colleges]]

Revision as of 02:12, 26 March 2013

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Introduction

Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.


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Filename: PHIL_1181_lores.jpg
Thumbnail status: |thumb|
Pixel size: |300px|
Placement on page: |right|
Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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General Information


Include some current research in each topic, with at least one figure showing data.

Male-killing Pathway


How and when Spiroplasma poulsonii selectively kills male Drosophila flies is a key part of understanding their host-pathogen relationship. Several papers have been published trying to uncover the specific pathway of male-killing that the bacterium causes. The dosage compensation complex (DCC) and programmed cell death, apoptosis, are two important portions that may be involved in the pathway.

Dosage Compensation Complex


Drosophila males differ from females by their number of X chromosomes; males have a single X while females have a pair. This genetic discrepancy is balanced through the hypertranscription of the male X chromosome by the dosage compensation complex. In females, a protein called Sex-lethal (SXL) inhibits the production of DCC components, preventing unnecessary dosage compensation. Male flies do not express the proper form of Sxl, and SXL cannot affect DCC components. Four proteins in the DCC have been tested using loss-of-function mutations. Mutant fly lines with these DCC components reduced or absent showed a reduction in male-specific lethality. This demonstrates that the DCC must be functional for Spiroplasma to successfully target and kill developing male flies. (Veneti et al., 2005)

Apoptosis


The other potential mechanism that causes male embryonic death is an increased number of male embryonic cells undergoing apoptosis, resulting in overall organism death. It has been found that male D. melanogaster embryos infected with the bacterium development slowed between stage 10 and stage 13 in embryogenesis and completely arrested in stage 13 about 10 hours after egg laying. Before stage 13, male embryos showed an increased amount of apoptotic cell death as compared to females. Apoptosis in uninfected individuals begins naturally at stage 10, the stage at which infected male embryos begin to die, suggesting that apoptosis is affected by the Spiroplasma bacterium.

Population Dynamics


Include some current research in each topic, with at least one figure showing data.

Conclusion


Overall paper length should be 3,000 words, with at least 3 figures.

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Veneti, Zoe et al. "A Functional Dosage Compensation Complex Required for Male Killing in Drosophila". Science. 2005. Volume 307. p. 1461-1463.

Bentley, Joanna K et al. “The pathology of embryo death caused by the male-killing Spiroplasma bacterium in Drosophila nebulosa”. BMC Biology. 2007. Volume 5.

Edited by Jennifer Martin, a student of Nora Sullivan in BIOL187S (Microbial Life) in The Keck Science Department of the Claremont Colleges Spring 2013.