Helicobacter pylori as a causative agent of Gastric Cancer: Difference between revisions

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[[Image:http://upload.wikimedia.org/wikipedia/commons/9/9a/H_pylori_virulence_factors_en.png|thumb|300px|right|Figure 5. <i>H. pylori</i> virulence factors.]]
[[Image:http://upload.wikimedia.org/wikipedia/commons/9/9a/H_pylori_virulence_factors_en.png|thumb|300px|right|Figure 5. <i>H. pylori</i> virulence factors.]]
<br><br>Other examples:
<br><b>Bold</b>
<br><i>Italic</i>
<br><b>Subscript:</b> H<sub>2</sub>O
<br><b>Superscript:</b> Fe<sup>3+</sup>


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Revision as of 17:44, 22 April 2015

Introduction

Figure 1. Transmission electron micrograph image of Helicobacter pylori taken by Dr. Yutaka Tsutsumi, Department of Pathology, Fujita Health University School of Medicine
File:Https://gi.jhsps.org/Upload/200802291540 18983 000.jpg
Figure 2. Hematoxylin and eosin (H&E) stained histological section of the stomach mucosa indicating colonization of H. pylori. Courtesy of Johns Hopkins Medicine.
File:Http://www.nature.com/nrc/journal/v4/n9/images/nrc1433-f1.jpg
Figure 3. Induction of Cytoxin-associated gene A (CagA) gene by H. Pylori as a mechanism of cellular and DNA regulatory inhibition.
File:Http://www.pubcan.org/images/large/Fig 4-04 A.jpg
Figure 4. Advanced Gastric Carcinoma.



Helicobacter pylori Description and Genome

Gastric Cancer

Symptoms and Treatment

Process of Infection

Adhesin

DNA Repair Pathways

Inflammation

Future Work

References

[1] Helicobacter pylori and Cancer. (2013, September 5). Retrieved April 17, 2015, from http://www.cancer.gov/cancertopics/causes-prevention/risk/infectious-agents/h-pylori-fact-sheet

[2] Machado, A. M. D., Figueiredo, C., Touati, E., Máximo, V., Sousa, S., Michel, V., & Rasmussen, L. J. (2009). Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clinical Cancer Research, 15(9), 2995-3002.

[3] Suganuma, M., Watanabe, T., Yamaguchi, K., Takahashi, A., & Fujiki, H. (2012). Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. Cancer letters, 322(2), 133-138.

[4] Kim, S. S., Ruiz, V. E., Carroll, J. D., & Moss, S. F. (2011). Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma. Cancer letters ,305(2), 228-238.

[5] Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: A combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001; 49(3):347–353.

[6] Maier, R. J., Fu, C., Gilbert, J., Moshiri, F., Olson, J., & Plaut, A. G. (1996). Hydrogen uptake hydrogenase in Helicobacter pylori. FEMS microbiology letters, 141(1), 71-76.

[7] Ottemann, K. M., & Lowenthal, A. C. (2002). Helicobacter pylori uses motility for initial colonization and to attain robust infection. Infection and immunity, 70(4), 1984-1990.

[8] D. Falush, T. Wirth, B. Linz, et. al., Traces of human migrations in Helicobacter pylori populations, Science 299 (2003).

[9] A. Dubois, T. Boren, Helicobacter pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol. 9 (2007).

[10] Mayo Clinic. (n.d.). Stomach Cancer. Retrieved April 17, 2015, from http://www.mayoclinic.org/diseases-conditions/stomach-cancer/basics/definition/con-20038197

[11] Stomach Cancer. (n.d.). Retrieved April 20, 2015, from http://www.mayoclinic.org/diseases-conditions/stomach-cancer/basics/treatment/con-20038197

[12] National Cancer Institute. (n.d.). Stomach Cancer: MedlinePlus. Retrieved April 17, 2015, from http://www.nlm.nih.gov/medlineplus/stomachcancer.html

[13] R.M. Peek Jr., M.J. Blaser, Helicobacter pylori and gastrointestinal tract adenocarcinomas, Nature 2 (2002) 28-37

[14] Bagnoli F, Buti L, Tompkins L, Covacci A, Amieva MR. Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proceedings of the National Academy of Science USA 2005; 102(45):16339–16344.

[15] André AR, Ferreira MV, Mota RM, et al. Gastric adenocarcinoma and Helicobacter pylori: Correlation with p53 mutation and p27 immunoexpression. Cancer Epidemiology 2010; 34(5):618–625.

[16] Ma JL, Zhang L, Brown LM, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. Journal of the National Cancer Institute 2012; 104(6):488-492.



Edited by Alexandra Kruse, student of Joan Slonczewski for BIOL 238 Microbiology, 2015, Kenyon College.