Ulcerative Colitis caused by Bacteria?
Introduction
Ulcerative colitis is a complex chronic inflammatory disease that affects the large intestine and the rectum. UC causes inflammation or sores in the lining of the colon and rectum. These ulcers form where inflammation has killed the cells that usually line the colon. Symptoms of ulcerative colitis include, but are not limited to abdominal cramps, diarrhea, anemia, weight loss, fatigue, rectal bleeding, loss of appetite, loss of bodily fluids and nutrients, joint pain, as well as others. These symptoms are also common symptoms of other Inflammatory Bowel Diseases (IBD) which makes diagnosis complicated. The exact pathogenesis of Ulcerative colitis in unknown and remains an important topic of research. Ulcerative colitis is found all over the world, but is most common in England, North America, and Northern Europe. Up to 20% of people with UC have a primary relative with the disease or another IBD which suggests that there may be a genetic component to the disease. It works for any image uploaded anywhere to MicrobeWiki. The insertion code consists of:
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Pathogenesis
The exact pathogenesis of Ulcerative Colits is unknown. Patients with UC show abnormalities in the response of their immune system. The immune system is chronically activated producing inflammation even in the absence of microbes. Ulcerative colitis is not caused by specific foods or stress, but these factors may worsen symptoms. One common theme researchers find is that patients with UC show elevated levels of microbes in their body. This has been shown in both animal models as well as clinical trials. Mice with targeted deletion of the interlukin-2 gene spontaneously develop Ulcerative colits in normal conditions, but fail to exhibit the disease in germ free environments(Sellon).
One study conducted on a twelve-year-old patient
Section 2
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Section 3
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Conclusion
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References
Edited by student of Joan Slonczewski for BIOL 238 Microbiology, 2009, Kenyon College.
